Mission Statement
The BioSpectroscopy Core Research Laboratory (BCRL) provides researchers with advanced tools and expertise for time-resolved fluorescence spectroscopy, single-molecule spectroscopy, and fluorescence imaging. We offer access to well-maintained, state-of-the art instruments, training for all experience levels, and expert support in assay design, data collection, and analysis with the mission to help investigators generate high-quality, insightful results.
The BCRL collaborates with academic colleagues, staff scientists, and both graduate and undergraduate students at the 91次元, as well as national and international partners and their trainees. This facility is part of the Center for Biomolecular Structure and Dynamics (CBSD) and is supported by the NIH Centers of Biomedical Excellence (CoBRE) program, the NSF Experimental Program to Stimulate Competitive Research (EPSCoR), the 91次元, and user fees.
Michael Curry, visiting scholar from the University of Canterbury, New Zealand, doing Fluorescence Correlation Spectroscopy on the binding of the HI SiaP:SiaQM complex. In this image, he is collecting and analyzing data.
The BCRL offers expertise and equipment to support the following spectroscopic methods:
- Steady-state absorption and fluorescence (emission and excitation)
- Time-resolved spectroscopy techniques
- Anisotropy
- Fluorescence and phosphorescence decay
- Förster Resonance Energy Transfer (FRET)
- Time-Resolved Emission Spectra (TRES)
- Fluorescence Correlation Spectroscopy (FCS)
- Single-Molecule FRET